Viagra and its Active Ingredient, Sildenafil

what drugs interfere with viagra?Viagra, also known by its active ingredient, sildenafil, is a medication primarily used to treat erectile dysfunction in men. Sildenafil is also present in other medications like Revatio, which treats pulmonary hypertension. It's crucial to know that sildenafil can have potential interactions with various other drugs, which can alter its effectiveness or cause harmful effects.

Specific Drug Interactions with Viagra

Viagra's interaction with specific drugs is highly clinically significant, and in some cases, it's advised to avoid combining them. For instance, fosamprenavir, a medication used to manage HIV/AIDS, is one such drug that shouldn't be taken with Viagra. Certain HIV medications, like protease inhibitors, can increase sildenafil citrate levels in the blood, while others like efavirenz and nevirapine can reduce sildenafil levels.

Antifungal Medications and Viagra

Certain antifungal medications, such as Diflucan (Pfizer), can also interact with Viagra, potentially leading to toxicity. These interactions may also occur with other antifungal drugs like ketoconazole or erythromycin (Ery-Tab). Therefore, it's essential to consult with a healthcare professional before taking these medications together.

Blood Pressure Medications and Viagra

Blood pressure medications are another category that can interfere with Viagra.

These include drugs such as amlodipine, losartan, and clonidine.

Additionally, individuals who take organic nitrates for blood pressure should avoid taking sildenafil.The combination can lead to an unsafe drop in blood pressure.

Importance of Diet when Taking Viagra

Another important factor to consider when taking Viagra is the timing and content of meals. Avoid taking Viagra with a large or high-fat meal. Viagra blood levels peak an hour after you swallow the tablet on an empty stomach. If you consume a large or high-fat meal before taking Viagra, the medication may lose its effectiveness and may take longer to start working.

Cannabis and its Products' Interactions with Viagra

Cannabis and its products, including cannabidiol (CBD), may interact with Viagra. However, the extent and nature of these interactions need further research. It's advisable to consult with a healthcare professional if you're considering using these products in conjunction with Viagra.

Consulting Healthcare Professionals

Given the potential for various drug interactions with Viagra, it's critical to consult with a healthcare professional, such as a doctor or pharmacist, before starting or modifying your medication regime. This is especially important if you're prescribed sildenafil through a telehealth service, like GoodRx Care. They can provide personalized advice based on your health history and the other medications you're taking to ensure safe and effective use of Viagra.

Remember, the information provided here is not exhaustive, and there might be other drugs that can interfere with Viagra. Always consult with a healthcare professional for personalized advice.


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Updated June 16, 2005